SysCODE is an interdisciplinary research consortium that involves 24 scientists from 7 institutions, whose mission is to use advances in developmental biology, computational and genome sciences, and tissue engineering to build organ parts from stem cells. The three organ parts are the tooth germ, pancreatic islet and the heart valve. Transplantation and tissue engineering, which historically addressed the need for organ repair, are limited by donor shortage and long-term complications. New, systematic methods to design and generate organ parts have the potential to transform medicine. Independent advances are converging, so that a fresh, bold approach – integrating knowledge and principles from genetics/genomics; developmental biology; computational science/bioinformatics; and bioengineering/materials science – puts within our grasp a MOLECULAR BLUEPRINT and structural architecture for organ assembly.